You cannot do any keyboard mapping with FontCreator, but you can mix the glyphs from several fonts in one font and map them to different codepoints. You do not have to follow the Unicode standard, though there are good reasons for doing so if you can.
First, you need to decide in which applications this font must work. If you want it to work only in Word, for example, then Word has plenty of options for remapping the keyboard. If you want it to work in all applications, then your options are limited.
One method that might work for your problem is to make a set of four typestyles: regular, bold, italic, and bold italic, and use the different typestyles to switch to different glyph designs within the same font. This is what I did with this set of Burmese fonts:
The regular Burmese uses the regular typestyle, the bold Burmese uses the Bold typestyle, the matching English font uses italic, and I also used bold italic for bold English letters.
I recommend keeping all the glyphs in a single font if possible. Switching fonts with keyboard macros is not very convenient. Switching from regular to bold or italic is not too difficult, and will work in most Windows applications. Unless you limit yourself to a customized keyboard in Word, however, a single font is going to be difficult to type with.