Not without getting clipped in most applications. Either use graphics for such characters so that text can wrap around them, or let them determine the default line-spacing for your font, and use fixed line spacing to keep regular sized text at the right specing.
The Gothic Drop Capital, Paragraph Leaders in my font Talapanna (like the A and M with the big descenders) when used with normal 10 point text single-line spacing would be spaced at 15 points per line, which is too wide, so I use the font with 12 point fixed line spacing, or 120% proportional line-spacing.
why no image showing up? size restriction?
Your image hosting service apparently does not allow linking from other websites. If you check with your ISP, you will probably have at least 20Mbytes of free server space that you can use to host your personal flles.